<p>The composition of MD-Tissue Guna has been rigorously developed to ensure its effectiveness in supporting connective tissue while meeting the strictest safety standards for injectable medical devices. Each bottle of 2 ml contains a sterile and pyrogen-free isotonic solution, suitable for administration by superficial or deep injection under medical supervision. The formulation does not contain parabens, irritating synthetic preservatives, or animal-derived substances other than collagen hydrolysate, the main active component.</p><p>Purified and titrated porcine-derived hydrolyzed collagen plays a fundamental role here as an essential structural element for the regeneration and strengthening of connective tissue. Its contribution, when administered locally, encourages the endogenous biosynthesis of new collagen, a key step in the processes of skin repair, joint support, and restoration of dermal support structures. An isotonic excipient based on sodium chloride and sterile water is added to this base,
<p>Before using the MD-Tissue Guna, it is imperative to be aware of the contraindications, precautions, and potential allergic risks associated with it. This device should not be injected in cases of known allergy to any of its components, particularly to animal-derived collagen (porcine). The application is also contraindicated in individuals with uncontrolled local or systemic infections, or active or exacerbated autoimmune diseases.</p><p>Additional precautions should be observed in individuals with a history of severe allergic reactions or hypersensitivity to exogenous proteins. Before any procedure, a thorough patient interview and, if necessary, a localized tolerance test may be conducted to assess individual risk. It is strongly advised not to apply this product to pregnant or breastfeeding women, as well as to children and adolescents due to the lack of safety data.</p><ul><li>Known allergy to collagen (main identified allergen)</li><li>History of allergy to animal or exogenous proteins</li><li>Active or decompensated autoimmune diseases</li><li>Presence of local infection or evolving dermatological condition</li><li>Avoid use during pregnancy or breastfeeding</li><li>Not indicated for pediatric subjects</li><li>Potential risk of localized swelling, redness, or pain</li><li>Increased monitoring recommended in atopic individuals</li></ul><p>In accordance with safety recommendations, any unusual reaction must be immediately reported to the healthcare professional, and prompt management organized in case of a severe reaction.</p>