<p>The composition of Plenhyage XL Thin is based on the high quality and purity of its ingredients, compliant with pharmaceutical standards for use in injected mesotherapy.<br>The main component is a solution of highly purified polynucleotides, extracted and processed according to rigorous protocols aimed at ensuring a total absence of pathogens and allergens. This approach guarantees a safe product, compatible with human tissues and devoid of significant immunogenic properties.</p><p>The polynucleotides are fragments of DNA chains obtained through a controlled polymerization process, with a molecular weight specifically adapted for optimal diffusion in the superficial dermal tissue. This configuration aims to promote water retention in the extracellular matrix, support fibroblast proliferation, and stimulate collagen synthesis.</p><p>In addition to the active ingredient, the solution contains sterile excipients: isotonic sodium chloride and water for injection preparation, intended to ensure physicochemical stability as well as perfect tolerance during injection. No additives, colorants, preservatives, or exogenous proteins are introduced into the formulation.</p><h3>Detailed composition (for 1 syringe of 2 ml)</h3><ul><li>Highly purified polynucleotides (PDRN, 2 mg/ml)</li><li>Sodium chloride (isotonic salt, concentration adapted to tissue tolerance)</li><li>Pyrogen-free water for injection preparation (sufficient quantity for 2 ml)</li></ul><p>The absence of allergenic substances and animal proteins makes the solution compatible with the majority of skin profiles, including sensitive subjects or those at low allergic risk. The polynucleotides, derived from controlled natural sources, undergo several purification steps, including ultrafiltration and terminal sterilization, to ensure their integrity and safety.</p><p>The packaging in a sterile single-dose syringe, under aseptic conditions, complements the product's safety device, helping to limit any exogenous interaction or risk of degradation during handling.</p><ul><li><strong>Main active ingredient:</strong> Purified polynucleotides</li><li><strong>Sterile excipients suitable for injection</strong></li><li><strong>No preservatives or colorants</strong></li><li><strong>No detectable presence of pathogenic proteins</strong></li><li><strong>Sterilization by validated technique</strong></li><li><strong>High skin compatibility</strong></li></ul><p>In summary, the composition of Plenhyage XL Thin combines safety, efficacy, and ease of use, meeting the strict standards expected in injectable aesthetic medicine.</p>
<p>Although the formulation of Plenhyage XL Thin is designed to limit allergic risks, certain precautions and contraindications must be observed. The product is free from detectable pathogenic proteins and contains no preservatives or synthetic additives, which significantly minimizes the allergenic potential.</p><p>However, the product should not be used in patients with:</p><ul><li>History of allergy or known hypersensitivity to polynucleotides or any excipient of the solution</li><li>Active autoimmune diseases</li><li>Ongoing infectious or inflammatory skin conditions in the area to be treated</li><li>Pregnancy or breastfeeding (lack of safety data)</li><li>Unstable heavy immunosuppressive treatments</li><li>Minors or non-consenting patients</li><li>History of severe reactions to injections or hyaluronic acid</li></ul><p>Occasional adverse effects are possible: hematoma, edema, erythema, pruritus—generally transient and self-resolving. In the case of a severe allergic reaction (significant edema, feeling unwell, breathing difficulties), it is recommended to stop the treatment immediately and contact a physician.</p><p>As a precaution, a prior medical interview is systematically advised as part of the aesthetic procedure to ensure the safe use of the product. Strict adherence to the usage recommendations also limits the risk of adverse events.</p>